Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPK (Q5VXJ0) - Overview - Molecular Target Synopsis

Protein


LIPK, Lipase member K
Enzyme Classification 3.1.1.-
UniProt Q5VXJ0

Also Known as LIPK_HUMAN, LIPK, LIPL2

Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
399ENSG00000204021ENST00000404190ENSP00000383900Q5VXJ0-1

Sub-cellular localization


UniProt: LIPK is active in the following subcellular-locations: secreted.
GO terms: LIPK is active in the following subcellular-locations: extracellular region, intracellular membrane-bounded organelle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPK has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RMUG-S, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to LIPK there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPK has been screened with compounds ( bioactivities). (see details)