Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LYPLAL1 (Q5VWZ2) - Overview - Molecular Target Synopsis

Protein


LYPLAL1, Lysophospholipase-like protein 1
Enzyme Classification 3.1.2.-
UniProt Q5VWZ2

Also Known as LYPL1_HUMAN, LYPLAL1

Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.

5KRE
COVALENT INHIBITOR OF LYPLAL1
RCSB/PDB
Inspect Structure
See all 3D Structures for LYPLAL1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
237ENSG00000143353ENST00000366928ENSP00000355895Q5VWZ2-1
221ENSG00000143353ENST00000366927ENSP00000355894Q5VWZ2-2

Sub-cellular localization


UniProt: LYPLAL1 is active in the following subcellular-locations: cytoplasm, cytosol.
GO terms: LYPLAL1 is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LYPLAL1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, NCI_H460, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H520, NCI-H322T, MOR

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, GM12878, K562

(see details)

3D Structures


For LYPLAL1 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LYPLAL1 has been screened with 13 compounds (13 bioactivities), 8 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)