Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RSBN1 (Q5VWQ0) - Overview - Molecular Target Synopsis

Protein


RSBN1, Lysine-specific demethylase 9
Enzyme Classification 1.14.11.-
UniProt Q5VWQ0

Also Known as RSBN1_HUMAN, RSBN1

Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
802ENSG00000081019ENST00000261441ENSP00000261441Q5VWQ0-1
459Q5VWQ0-4
399ENSG00000081019ENST00000476412ENSP00000433256

Sub-cellular localization


UniProt: RSBN1 is active in the following subcellular-locations: nucleus.
GO terms: RSBN1 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RSBN1 has gain in 7 cell-lines, loss in 3 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, MCF7, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, SUP-B15, NCI-H345

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, A549

(see details)

3D Structures


At greater than 35% identity similarity to RSBN1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis