Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

OBSCN (Q5VST9) - Overview - Molecular Target Synopsis

Protein


OBSCN, Obscurin
Enzyme Classification 2.7.11.1
UniProt Q5VST9

Also Known as OBSCN_HUMAN, OBSCN, KIAA1556, KIAA1639

Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). Interacts (via protein kinase domain 2) with CDH2 and (via protein kinase domain 1) with ATP1B1 (By similarity). Isoform 3 interacts with TTN/titin and calmodulin (PubMed:11448995, PubMed:11717165). Isoform 3 interacts with ANK1 isoform Mu17/ank1.5 (PubMed:12527750).

6MG9
HUMAN OBSCURIN IG57 DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for OBSCN

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: OBSCN is active in the following subcellular-locations: cell membrane, cytoplasm, m line, myofibril, nucleus, sarcolemma, sarcomere, z line.
GO terms: OBSCN is active in the following subcellular-locations: cytosol, M band, myofibril, nuclear body, plasma membrane, sarcolemma, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project OBSCN has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, A498, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2688, MHH-ES-1, Hs 675.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD34-positive mobilized cell, NHLF, HSMM

(see details)

RNA Interference


OBSCN was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CROE33, OVAS. (see details)

3D Structures


For OBSCN there are:
23 structures (40 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


OBSCN has been screened with compounds ( bioactivities). (see details)