Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

OBSCN (Q5VST9) - Overview - Molecular Target Synopsis


OBSCN, Obscurin
Enzyme Classification
UniProt Q5VST9

Also Known as OBSCN_HUMAN, OBSCN, KIAA1556, KIAA1639

Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). Interacts (via protein kinase domain 2) with CDH2 and (via protein kinase domain 1) with ATP1B1 (By similarity). Isoform 3 interacts with TTN/titin and calmodulin (PubMed:11448995, PubMed:11717165). Isoform 3 interacts with ANK1 isoform Mu17/ank1.5 (PubMed:12527750).

Inspect Structure
See all 3D Structures for OBSCN

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: OBSCN is active in the following subcellular-locations: cell membrane, cytoplasm, m line, myofibril, nucleus, sarcolemma, sarcomere, z line.
GO terms: OBSCN is active in the following subcellular-locations: cytosol, M band, myofibril, nuclear body, plasma membrane, sarcolemma, Z disc.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project OBSCN has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, A498, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2688, MHH-ES-1, Hs 675.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD34-positive mobilized cell, NHLF, HSMM

(see details)

RNA Interference

OBSCN was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CROE33, OVAS. (see details)

3D Structures

For OBSCN there are:
23 structures (40 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

OBSCN has been screened with compounds ( bioactivities). (see details)