Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD17B (Q5VST6) - Overview - Molecular Target Synopsis

Protein


ABHD17B, Alpha/beta hydrolase domain-containing protein 17B
Enzyme Classification 3.1.2.22
UniProt Q5VST6

Also Known as AB17B_HUMAN, ABHD17B, C9orf77, FAM108B1

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
293ENSG00000107362ENST00000377041ENSP00000366240Q5VST6-2
288ENSG00000107362ENST00000333421ENSP00000330222Q5VST6-1

Sub-cellular localization


UniProt: ABHD17B is active in the following subcellular-locations: cell junction, cell membrane, cell projection, dendritic spine, postsynaptic cell membrane, postsynaptic density, recycling endosome membrane, synapse.
GO terms: ABHD17B is active in the following subcellular-locations: anchored component of postsynaptic density membrane, anchored component of postsynaptic recycling endosome membrane, cell junction, dendritic spine, glutamatergic synapse, membrane, recycling endosome membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD17B has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, OCI-LY-19, SUP-B15

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, NHLF, HSMM

(see details)


Screening and Chemistry


ABHD17B has been screened with 3 compounds (3 bioactivities). (see details)