CROCC (Q5TZA2) - Overview - Molecular Target Synopsis
Also Known as CROCC_HUMAN, CROCC, KIAA0445
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: CROCC is active in the following subcellular-locations: centriole, centrosome, cilium basal body, cytoplasm, cytoskeleton, microtubule organizing center.
GO terms: CROCC is active in the following subcellular-locations: actin cytoskeleton, centriole, centrosome, ciliary rootlet, cytosol, extracellular exosome, photoreceptor inner segment, plasma membrane.