Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CROCC (Q5TZA2) - Overview - Molecular Target Synopsis

Protein


CROCC, Rootletin
UniProt Q5TZA2

Also Known as CROCC_HUMAN, CROCC, KIAA0445

Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
2017ENSG00000058453ENST00000375541ENSP00000364691Q5TZA2-1
1313Q5TZA2-2
1280ENSG00000058453ENST00000445545ENSP00000402626

Sub-cellular localization


UniProt: CROCC is active in the following subcellular-locations: centriole, centrosome, cilium basal body, cytoplasm, cytoskeleton, microtubule organizing center.
GO terms: CROCC is active in the following subcellular-locations: actin cytoskeleton, centriole, centrosome, ciliary rootlet, cytosol, extracellular exosome, photoreceptor inner segment, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CROCC has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H82, SCLC-21H, MHH-ES-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)