Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIN9 (Q5TKA1) - Overview - Molecular Target Synopsis

Protein


LIN9, Protein lin-9 homolog
UniProt Q5TKA1

Also Known as LIN9_HUMAN, LIN9, BARA, TGS

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1.

6C48
CRYSTAL STRUCTURE OF B-MYB-LIN9-LIN52 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for LIN9

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LIN9 is active in the following subcellular-locations: nucleoplasm, nucleus.
GO terms: LIN9 is active in the following subcellular-locations: nucleoplasm, transcriptional repressor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIN9 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, TK_10, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC38, HCC1599, WSU-FSCCL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures


For LIN9 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis