Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TTBK1 (Q5TCY1) - Overview - Molecular Target Synopsis

Protein


TTBK1, Tau-tubulin kinase 1
Enzyme Classification 2.7.11.1
UniProt Q5TCY1

Also Known as TTBK1_HUMAN, TTBK1, BDTK, KIAA1855

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.

4NFM
HUMAN TAU TUBULIN KINASE 1 (TTBK1)
RCSB/PDB
Inspect Structure
See all 3D Structures for TTBK1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1321ENSG00000146216ENST00000259750ENSP00000259750Q5TCY1-1
675ENSG00000146216ENST00000304139ENSP00000307357
621Q5TCY1-2

Sub-cellular localization


UniProt: TTBK1 is active in the following subcellular-locations: cytoplasm.
GO terms: TTBK1 is active in the following subcellular-locations: cytoplasm, cytosol, microtubule associated complex, neuronal cell body, nucleoplasm, nucleus, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TTBK1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, MOLT_4, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-21H, SK-N-FI, KELLY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


TTBK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BT474, HCC202. (see details)

3D Structures


For TTBK1 there are:
5 structures (7 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TTBK1 has been screened with 9 compounds (11 bioactivities). (see details)