Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP3K21 (Q5TCX8) - Overview - Molecular Target Synopsis

Protein


MAP3K21, Mitogen-activated protein kinase kinase kinase 21
Enzyme Classification 2.7.11.25
UniProt Q5TCX8

Also Known as M3K21_HUMAN, MAP3K21, KIAA1804, MLK4

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. Homodimer (By similarity). Interacts with TLR4.

4UYA
STRUCTURE OF MLK4 KINASE DOMAIN WITH ATPGAMMAS
RCSB/PDB
Inspect Structure
See all 3D Structures for MAP3K21

Isoforms / Transcripts (Protein Coding)


Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP3K21 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

RNA Interference


MAP3K21 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HUO9, G292. (see details)

3D Structures


For MAP3K21 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAP3K21 has been screened with compounds ( bioactivities). (see details)