Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

L1TD1 (Q5T7N2) - Overview - Molecular Target Synopsis

Protein


L1TD1, LINE-1 type transposase domain-containing protein 1
UniProt Q5T7N2

Also Known as LITD1_HUMAN, L1TD1, ECAT11


2LR6
NMR STRUCTURE OF A LINE-1 TYPE TRANSPOSASE DOMAIN-CONTAINING PROTEIN 1 (L1TD1) FROM HOMO SAPIENS
RCSB/PDB
Inspect Structure
See all 3D Structures for L1TD1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
865ENSG00000240563ENST00000498273ENSP00000419901Q5T7N2-1

Sub-cellular localization


GO terms: L1TD1 is active in the following subcellular-locations: ribonucleoprotein complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project L1TD1 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NTERA-2, OV-90, DU4475

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: H1-hESC, SK-N-SH, NHLF

(see details)

3D Structures


For L1TD1 there are:
2 structures (5 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis