Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC10 (Q5T3U5) - Overview - Molecular Target Synopsis

Protein


ABCC10, Multidrug resistance-associated protein 7
UniProt Q5T3U5

Also Known as MRP7_HUMAN, ABCC10, MRP7, SIMRP7

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCC10 is active in the following subcellular-locations: cell membrane.
GO terms: ABCC10 is active in the following subcellular-locations: integral component of membrane, lysosomal membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC10 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SR, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: YAPC, HCC2270, HCC4011

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)

3D Structures


At greater than 35% identity similarity to ABCC10 there are:
79 structures (134 chains) solved
48 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ABCC10 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6MSM_A, 6QEE_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC10 has been screened with 29 compounds (31 bioactivities). (see details)