Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LRIF1 (Q5T3J3) - Overview - Molecular Target Synopsis

Protein


LRIF1, Ligand-dependent nuclear receptor-interacting factor 1
UniProt Q5T3J3

Also Known as LRIF1_HUMAN, LRIF1, C1orf103, RIF1

Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Interacts with RARA (PubMed:17455211). Interacts with SMCHD1; leading to recruitment to inactivated chromosome X in females (PubMed:23542155). Interacts (via PxVxL motif) with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha) (PubMed:23542155).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
769ENSG00000121931ENST00000369763ENSP00000358778Q5T3J3-1
233ENSG00000121931ENST00000494675, ENST00000485275ENSP00000435259, ENSP00000432290Q5T3J3-2

Sub-cellular localization


UniProt: LRIF1 is active in the following subcellular-locations: chromosome, nucleus matrix.
GO terms: LRIF1 is active in the following subcellular-locations: Barr body, microtubule organizing center, nuclear matrix, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LRIF1 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-3, OVCAR-8, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, HMEC

(see details)