Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

LRIF1 (Q5T3J3) - Overview - Molecular Target Synopsis


LRIF1, Ligand-dependent nuclear receptor-interacting factor 1
UniProt Q5T3J3

Also Known as LRIF1_HUMAN, LRIF1, C1orf103, RIF1

Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Interacts with RARA (PubMed:17455211). Interacts with SMCHD1; leading to recruitment to inactivated chromosome X in females (PubMed:23542155). Interacts (via PxVxL motif) with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha) (PubMed:23542155).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
233ENSG00000121931ENST00000494675, ENST00000485275ENSP00000435259, ENSP00000432290Q5T3J3-2

Sub-cellular localization

UniProt: LRIF1 is active in the following subcellular-locations: chromosome, nucleus matrix.
GO terms: LRIF1 is active in the following subcellular-locations: Barr body, microtubule organizing center, nuclear matrix, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project LRIF1 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-3, OVCAR-8, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, HMEC

(see details)