Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(Q5SMG8) - Overview - Molecular Target Synopsis

Protein


, Magnesium transporter MgtE
UniProt Q5SMG8

Also Known as MGTE_THET8

Acts as a highly selective magnesium channel. Homodimer.

5X9H
CRYSTAL STRUCTURE OF THE MG2+ CHANNEL MGTE IN COMPLEX WITH ATP
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
450Q5SMG8-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: cell membrane.
GO terms: is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
9 structures (21 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis