Molecular Target Synopsis
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rplA (Q5SLP7) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria5


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
487D_H 50S ribosomal protein L1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 75.4 41 Yes Yes
2 empty 2.52 60.8 28.5 No No
3 empty 2.31 61.6 14.4 No No
4 empty 2.38 63 23.8 No No
5 empty 2.36 59.1 18.9 No No
6 empty 2.12 51.8 14.9 No No
7 empty 2.26 64.5 14.7 No No
8 empty 2.07 72.3 9.8 No No
9 empty 1.98 55.7 11 No No
10 empty 2.22 59.2 9.9 No No
2OV7_A 50S ribosomal protein L1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.83 63.6 22.9 No No
2 empty 2.49 62.7 17.5 No No
3 empty 2.19 62.4 13.9 No No
4 empty 2.37 66.1 19.8 No No
5 empty 2.68 66.1 12.7 No No
6 empty 2.07 64.3 10.1 No No
7 empty 1.63 68.3 8.9 No No
8 empty 1.91 62 13.5 No No
9 empty 2.56 65.1 14.4 No No
10 empty 2.45 53.8 13.4 No No
2OM7_K 50S ribosomal protein L1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 74 57.2 Yes Yes
2 empty 2.13 63 14 No No
3 empty 2.15 50.4 14.5 No No
4 empty 2.49 70.3 15.9 No No
5 empty 2.2 77.9 9.4 No No
6 empty 2.07 69.5 9.2 No No
7 empty 2.25 60.4 13.2 No No
8 empty 2.98 62.5 8.1 No No
9 empty 2.14 63.6 8.6 No No
10 empty 2.73 64.9 7.2 No No
2OUM_A 50S ribosomal protein L1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 54.9 20.7 No No
2 empty 2.29 65.7 16.7 No No
3 empty 1.55 69.6 10.2 No No
4 empty 2.51 62.2 16.1 No No
5 empty 2.73 68.6 14.3 No No
6 empty 2.02 62.6 10 No No
7 empty 2.32 56.1 17 No No
8 empty 2.14 70.8 8.6 No No
9 empty 2.34 56.3 13.6 No No
10 empty 1.77 67.9 10.5 No No
2OV7_C 50S ribosomal protein L1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.77 64.1 26.6 Yes No
2 empty 1.65 66.8 13.3 No No
3 empty 2.61 65 16.2 No No
4 empty 2.28 61.5 18.1 No No
5 empty 2.3 65.4 12.6 No No
6 empty 2.24 61.8 12.6 No No
7 empty 2.39 69.9 11.3 No No
8 empty 2.21 63.9 14.4 No No
9 empty 2.57 64 10.2 No No
10 empty 1.63 60.2 11.4 No No
5NPM_A 50S ribosomal protein L1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 68.4 36.1 Yes Yes
2 empty 2.15 65.2 15 No No
3 empty 2.42 62.2 18.6 No No
4 empty 2.09 61 14.4 No No
5 empty 1.94 60.6 10.5 No No
6 empty 2.11 68.6 8.1 No No
7 empty 2.08 64.8 9.1 No No
8 empty 2.29 52.3 11.2 No No
9 empty 2.05 63.2 8.9 No No
10 empty 2.42 68.5 7.2 No No
2OV7_B 50S ribosomal protein L1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 61.9 21.6 No No
2 empty 2.53 61.6 17.6 No No
3 empty 2.89 58.7 14.9 No No
4 empty 2.04 66.9 15.7 No No
5 empty 2.42 63.8 12.5 No No
6 empty 2.61 64.2 12.5 No No
7 empty 1.67 67.9 9 No No
8 empty 2.49 63.9 14.6 No No
9 empty 2.79 82.2 9 No No
10 empty 2.13 61.8 8.8 No No
3TG8_A 50S ribosomal protein L1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 62.9 38.6 Yes No
2 bound 1.92 59.9 17.7 No No
3 bound 2.66 61.2 16.8 No No
4 empty 2.21 63.6 16.5 No No
5 empty 2.23 51.9 16.4 No No
6 empty 2 84 7.7 No No
7 empty 2.72 55.5 8.3 No No
8 empty 2.23 68.3 8 No No
9 empty 2.76 61.5 8.5 No No
10 empty 2.63 61.7 9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed41
Domains assessed as druggable using the strict criteria30
Domains assessed as druggable using the relaxed criteria41

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2J01_C (137861) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, Ribosomal protein L1 2.8Å Yes Yes
2J03_C (137887) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, Ribosomal protein L1 2.8Å Yes Yes
2OM7_K (148867) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, Ribosomal protein L1 7.3Å Yes Yes
2V47_C (152509) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, Ribosomal protein L1 3.5Å Yes Yes
2WDI_C (3240311) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.3Å Yes Yes
2WDJ_C (3240346) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.3Å Yes Yes
2WDL_C (3240404) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.4Å Yes Yes
2WDN_C (3240462) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.4Å Yes Yes
2WH2_C (3240695) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.45Å Yes Yes
2WH4_C (3240759) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.45Å Yes Yes
2WRJ_C (3250365) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.6Å Yes No
2WRL_C (3250428) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.6Å Yes No
2WRO_C (3250490) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.6Å Yes No
2WRR_C (3250551) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.6Å Yes No
2X9S_C (3260965) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes Yes
2X9U_C (3270026) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes Yes
2XG0_C (3270463) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.2Å Yes Yes
2XG2_C (3270522) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.2Å Yes Yes
2XQE_C (3580900) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes Yes
2XTG_C (3590102) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 7.8Å Yes Yes
2XUX_C (3590212) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 7.6Å Yes No
2Y0V_C (3590717) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes No
2Y0X_C (3590776) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes No
2Y0Z_C (3590835) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes No
2Y11_C (3590894) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes Yes
2Y13_C (3590953) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes No
2Y15_C (3600012) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes No
2Y17_C (3600071) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes Yes
2Y19_C (3600130) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes Yes
3FIN_C (3410239) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 6.4Å Yes Yes
3HUX_C (3460733) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes Yes
3HUZ_C (3460794) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.1Å Yes No
3KIR_C (3500749) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.3Å Yes Yes
3KIT_C (3500809) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.3Å Yes Yes
3KIW_C (3500869) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.6Å Yes Yes
3KIY_C (3500929) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.6Å Yes Yes
3KNI_C (3510258) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3Å Yes Yes
3KNK_C (3510316) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3Å Yes Yes
3KNM_C (3510374) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.4Å Yes Yes
3KNO_C (3510432) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.4Å Yes Yes
3ZVP_C (3720138) 50S ribosomal protein L1 Ribosomal protein L1, Ribosomal protein L1, UNMATCHED 3.8Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score