Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

infC (Q5SKU2) - Overview - Molecular Target Synopsis

Protein


infC, Translation initiation factor IF-3
UniProt Q5SKU2

Also Known as IF3_THET8, infC

IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. Monomer. Binds to proteins S7, S11 and S18 of the small ribosomal subunit.

5LMQ
STRUCTURE OF BACTERIAL 30S-IF1-IF3-MRNA-TRNA TRANSLATION PRE- INITIATION COMPLEX, OPEN FORM (STATE-2A)
RCSB/PDB
Inspect Structure
See all 3D Structures for infC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
171Q5SKU2-1, Q70YI5-1, Q9ACJ8-1

Sub-cellular localization


UniProt: infC is active in the following subcellular-locations: cytoplasm.
GO terms: infC is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project infC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For infC there are:
10 structures (10 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

infC is solved in complex with the approved drug(s):

A/ADENOSINE PHOSPHATE (5LMO_X).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


infC has been screened with compounds ( bioactivities). (see details)