Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

thiG (Q5SKG7) - Overview - Molecular Target Synopsis

Protein


thiG, Thiazole synthase
Enzyme Classification 2.8.1.10
UniProt Q5SKG7

Also Known as THIG_THET8, thiG

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. Homotetramer. Forms heterodimers with either ThiH or ThiS.

2HTM
CRYSTAL STRUCTURE OF TTHA0676 FROM THERMUS THERMOPHILUS HB8
RCSB/PDB
Inspect Structure
See all 3D Structures for thiG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
268Q5SKG7-1

Sub-cellular localization


UniProt: thiG is active in the following subcellular-locations: cytoplasm.
GO terms: thiG is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project thiG has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For thiG there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis