Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpsO (Q5SJ76) - Overview - Molecular Target Synopsis

Protein


rpsO, 30S ribosomal protein S15
UniProt Q5SJ76

Also Known as RS15_THET8, rpsO

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA., Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

6MPF
STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT COMPLEXED WITH A 2-THIOCYTIDINE (S2C32) AND INOSINE (I34) MODIFIED ANTICODON STEM LOOP (ASL) OF ESCHERICHIA COLI TRANSFER RNA ARGININE 1 (TRNAARG1) BOUND TO AN MRNA WITH AN CGC-CODON IN THE A-SITE AND PAROMOMYCIN
RCSB/PDB
Inspect Structure
See all 3D Structures for rpsO

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpsO is active in the following subcellular-locations: ribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpsO has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpsO there are:
127 structures (128 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis