Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rplV (Q5SHP3) - Overview - Molecular Target Synopsis

Protein


rplV, 50S ribosomal protein L22
UniProt Q5SHP3

Also Known as RL22_THET8, rplV

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)., The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome. This extension seems to form part of the wall of the exit tunnel. Part of the 50S ribosomal subunit.

1ML5
STRUCTURE OF THE E. COLI RIBOSOMAL TERMINATION COMPLEX WITH RELEASE FACTOR 2
RCSB/PDB
Inspect Structure
See all 3D Structures for rplV

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rplV is active in the following subcellular-locations: large ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rplV has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rplV there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis