Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC27A3 (Q5K4L6) - Overview - Molecular Target Synopsis

Protein


SLC27A3, Solute carrier family 27 member 3
Enzyme Classification 6.2.1.-
UniProt Q5K4L6

Also Known as S27A3_HUMAN, SLC27A3, ACSVL3, FATP3

Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
730ENSG00000143554ENST00000368661ENSP00000357650Q5K4L6-1
695Q5K4L6-2
276Q5K4L6-3

Sub-cellular localization


UniProt: SLC27A3 is active in the following subcellular-locations: mitochondrion membrane.
GO terms: SLC27A3 is active in the following subcellular-locations: endoplasmic reticulum, integral component of membrane, membrane, mitochondrial membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC27A3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, UACC_257, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-257, IGR-37, COLO 829

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, HSMM

(see details)


Screening and Chemistry


SLC27A3 has been screened with compounds ( bioactivities). (see details)