Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EPHA10 (Q5JZY3) - Overview - Molecular Target Synopsis

Protein


EPHA10, Ephrin type-A receptor 10
Enzyme Classification 2.7.10.1
UniProt Q5JZY3

Also Known as EPHAA_HUMAN, EPHA10

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: EPHA10 is active in the following subcellular-locations: cell membrane, secreted.
GO terms: EPHA10 is active in the following subcellular-locations: extracellular region, integral component of membrane, integral component of plasma membrane, neuron projection, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EPHA10 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_15, TK_10, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H510A, SCLC-21H, YMB-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


EPHA10 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BXPC3, NOS1. (see details)

3D Structures


At greater than 50% identity similarity to EPHA10 there are:
73 structures (136 chains) solved
40 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

EPHA10 is solved in complex with the approved drug(s):

1N1/DASATINIB (2Y6O_A, 6FNM_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


EPHA10 has been screened with compounds ( bioactivities). (see details)