Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

EPHA10 (Q5JZY3) - Overview - Molecular Target Synopsis


EPHA10, Ephrin type-A receptor 10
Enzyme Classification
UniProt Q5JZY3

Also Known as EPHAA_HUMAN, EPHA10

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: EPHA10 is active in the following subcellular-locations: cell membrane, secreted.
GO terms: EPHA10 is active in the following subcellular-locations: extracellular region, integral component of membrane, integral component of plasma membrane, neuron projection, plasma membrane, receptor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project EPHA10 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HCT_15, TK_10, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H510A, SCLC-21H, YMB-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

EPHA10 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BXPC3, NOS1. (see details)

3D Structures

At greater than 50% identity similarity to EPHA10 there are:
78 structures (146 chains) solved
41 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

EPHA10 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

EPHA10 has been screened with compounds ( bioactivities). (see details)