Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GLRA4 (Q5JXX5) - Overview - Molecular Target Synopsis

Protein


GLRA4, Glycine receptor subunit alpha-4
UniProt Q5JXX5

Also Known as GLRA4_HUMAN, GLRA4

Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Homopentamer (in vitro). Pentamer composed of alpha and beta subunits.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
417ENSG00000188828ENST00000372617ENSP00000361700Q5JXX5-1
44ENSG00000188828ENST00000436213ENSP00000412480

Sub-cellular localization


UniProt: GLRA4 is active in the following subcellular-locations: cell junction, cell membrane, cell projection, dendrite, perikaryon, postsynaptic cell membrane, synapse.
GO terms: GLRA4 is active in the following subcellular-locations: cell junction, chloride channel complex, dendrite, glycinergic synapse, integral component of plasma membrane, integral component of postsynaptic specialization membrane, neuron projection, perikaryon, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GLRA4 has gain in 2 cell-lines, loss in 30 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to GLRA4 there are:
5 structures (25 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GLRA4 has been screened with compounds ( bioactivities). (see details)