Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ZNF484 (Q5JVG2) - Overview - Molecular Target Synopsis

Protein


ZNF484, Zinc finger protein 484
UniProt Q5JVG2

Also Known as ZN484_HUMAN, ZNF484

May be involved in transcriptional regulation.

2YTP
SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGER (REGION 687- 719) OF HUMAN ZINC FINGER PROTEIN 484
RCSB/PDB
Inspect Structure
See all 3D Structures for ZNF484

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ZNF484 is active in the following subcellular-locations: nucleus.
GO terms: ZNF484 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ZNF484 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L88, NCI-H2196, NCI-H2198

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HMEC

(see details)

3D Structures


For ZNF484 there are:
13 structures (13 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ZNF484 has been screened with compounds ( bioactivities). (see details)