Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB41 (Q5JT25) - Overview - Molecular Target Synopsis

Protein


RAB41, Ras-related protein Rab-41
UniProt Q5JT25

Also Known as RAB41_HUMAN, RAB41

Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB41 is active in the following subcellular-locations: cytoplasm.
GO terms: RAB41 is active in the following subcellular-locations: cytosol, Golgi apparatus, Golgi membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB41 has gain in 0 cell-lines, loss in 29 cell-lines and no signal in 976 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, A-375, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to RAB41 there are:
4 structures (9 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis