Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EEF1AKMT2 (Q5JPI9) - Overview - Molecular Target Synopsis

Protein


EEF1AKMT2, EEF1A lysine methyltransferase 2
Enzyme Classification 2.1.1.-
UniProt Q5JPI9

Also Known as EFMT2_HUMAN, EEF1AKMT2, C10orf138, METTL10

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
291ENSG00000203791ENST00000368836ENSP00000357829Q5JPI9-1
37ENSG00000203791ENST00000495711ENSP00000470332

Sub-cellular localization


UniProt: EEF1AKMT2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: EEF1AKMT2 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EEF1AKMT2 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)