Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

COQ5 (Q5HYK3) - Overview - Molecular Target Synopsis

Protein


COQ5, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Enzyme Classification 2.1.1.201
UniProt Q5HYK3

Also Known as COQ5_HUMAN, COQ5

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: COQ5 is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: COQ5 is active in the following subcellular-locations: extrinsic component of mitochondrial inner membrane, mitochondrial matrix, mitochondrion, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project COQ5 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_257, HOP_62, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, MKN-45, HM7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, SK-N-SH

(see details)

3D Structures


At greater than 35% identity similarity to COQ5 there are:
2 structures (8 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis