Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ESCO1 (Q5FWF5) - Overview - Molecular Target Synopsis

Protein


ESCO1, N-acetyltransferase ESCO1
Enzyme Classification 2.3.1.-
UniProt Q5FWF5

Also Known as ESCO1_HUMAN, ESCO1, EFO1, KIAA1911

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). The subunit structure is controversial. Monomer (PubMed:27803161). Homodimer (PubMed:27112597).

5T53
MOLECULAR BASIS FOR COHESIN ACETYLATION BY ESTABLISHMENT OF SISTER CHROMATID COHESION N-ACETYLTRANSFERASE ESCO1
RCSB/PDB
Inspect Structure
See all 3D Structures for ESCO1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
840ENSG00000141446ENST00000269214ENSP00000269214Q5FWF5-1
701ENSG00000141446ENST00000383276ENSP00000372763Q5FWF5-2

Sub-cellular localization


UniProt: ESCO1 is active in the following subcellular-locations: chromosome, nucleus.
GO terms: ESCO1 is active in the following subcellular-locations: chromatin, chromosome, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ESCO1 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, UACC_257, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-45, NCI-H209, WSU-FSCCL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, HSMM

(see details)

3D Structures


For ESCO1 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis