Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSBG2 (Q5FVE4) - Overview - Molecular Target Synopsis

Protein


ACSBG2, Long-chain-fatty-acid--CoA ligase ACSBG2
Enzyme Classification 6.2.1.3
UniProt Q5FVE4

Also Known as ACBG2_HUMAN, ACSBG2, BGR

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSBG2 is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: ACSBG2 is active in the following subcellular-locations: cytoplasm, cytosol, membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSBG2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, OVCAR_8, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)