Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

fitB (Q5F882) - Overview - Molecular Target Synopsis

Protein


fitB, Toxin FitB
Enzyme Classification 3.1.-.-
UniProt Q5F882

Also Known as FITB_NEIG1, fitB, vapC

Toxic component of a type II toxin-antitoxin (TA) system. Plays a role in the speed with which bacteria traverse human epithelial cells; disruption of the locus increases the speed of trafficking about 2-4-fold. FitAB binds to its own promoter better than FitA alone. The expected nuclease activity was not observed for the FitAB complex, perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB. Forms a heterodimer with FitA, 4 FitAB heterodimers form a complex that binds to promoter DNA. The complex is also seen in solution. This protein does not actually contact DNA.

2H1C
CRYSTAL STRUCTURE OF FITACB FROM NEISSERIA GONORRHOEAE
RCSB/PDB
Inspect Structure
See all 3D Structures for fitB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
139Q5F882-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project fitB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fitB there are:
3 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis