Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
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Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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fitA (Q5F881) - Overview - Molecular Target Synopsis

Protein


fitA, Antitoxin FitA
UniProt Q5F881

Also Known as FITA_NEIG1, fitA, vapB

Antitoxin component of a type II toxin-antitoxin (TA) system. Plays a role in the speed with which bacteria traverse human epithelial cells; disruption of the locus increases the speed of trafficking about 2-4-fold. Binds to its own promoter, binding affinity of the FitAB complex is 20-30-fold higher than FitA alone. No nuclease activity was observed for the FitAB complex, perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB. Homodimer in the absence of FitB; forms a heterodimer with FitB; 4 FitAB heterodimers form a complex that binds to fitAB promoter DNA. The complex is also seen in solution.

2H1C
19 RESIDUE FRAGMENT OF
TRAFFICKING PROTEIN A
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF FITACB FROM NEISSERIA GONORRHOEAE
RCSB/PDB
Inspect Structure
See all 3D Structures for fitA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
78Q5F881-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project fitA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fitA there are:
3 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis