Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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Rassf5 (Q5EBH1) - Overview - Molecular Target Synopsis

Protein


Rassf5, Ras association domain-containing protein 5
UniProt Q5EBH1

Also Known as RASF5_MOUSE, Rassf5, Nore1, Rapl

Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS. Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation.

2YMY
STRUCTURE OF THE MURINE NORE1-SARAH DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for Rassf5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
413Q5EBH1-1
265Q5EBH1-2

Sub-cellular localization


UniProt: Rassf5 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: Rassf5 is active in the following subcellular-locations: cytoplasm, microtubule, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Rassf5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Rassf5 there are:
4 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis