Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NCE103 (Q5AJ71) - Overview - Molecular Target Synopsis

Protein


NCE103, Carbonic anhydrase
Enzyme Classification 4.2.1.1
UniProt Q5AJ71

Also Known as CAN_CANAL, NCE103

Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Acts as a CO(2) chemosensor and induces CO(2)-mediated filamentation. Essential for pathological growth in niches where sufficient CO(2) is not supplied by the host. Necessary for white-to-opaque switching at low CO(2) concentrations.

6GWU
CARBONIC ANHYDRASE CANCE103P FROM CANDIDA ALBICANS
RCSB/PDB
Inspect Structure
See all 3D Structures for NCE103

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
281Q5AJ71-1

Sub-cellular localization


UniProt: NCE103 is active in the following subcellular-locations: cytoplasm, mitochondrion intermembrane space, nucleus.
GO terms: NCE103 is active in the following subcellular-locations: cytoplasm, mitochondrial intermembrane space, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NCE103 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For NCE103 there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NCE103 has been screened with 198 compounds (327 bioactivities), 110 compounds have bioactivities that show binding affinity of <= 500nM (127 bioactivities). (see details)