Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TNNI3K (Q59H18) - Overview - Molecular Target Synopsis

Protein


TNNI3K, Serine/threonine-protein kinase TNNI3K
Enzyme Classification 2.7.11.1
UniProt Q59H18

Also Known as TNI3K_HUMAN, TNNI3K, CARK

May play a role in cardiac physiology. Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.

6B5J
TNNI3K COMPLEXED WITH A 4,6-DIAMINOPYRIMIDINE
RCSB/PDB
Inspect Structure
See all 3D Structures for TNNI3K

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TNNI3K is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TNNI3K is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TNNI3K has gain in 3 cell-lines, loss in 5 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, HL_60, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For TNNI3K there are:
3 structures (12 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TNNI3K has been screened with 178 compounds (249 bioactivities), 73 compounds have bioactivities that show binding affinity of <= 500nM (112 bioactivities). (see details)