Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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mycG (Q59523) - Overview - Molecular Target Synopsis

Protein


mycG, Mycinamicin IV hydroxylase/epoxidase
Enzyme Classification 1.14.-.-
UniProt Q59523

Also Known as MYCG_MICGR, mycG

Involved in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic. Catalyzes consecutive hydroxylation (at C14) and epoxidation (at C12-C13) reactions with mycinamicin IV as initial substrate, leading to mycinamicin II. These reactions require prior dimethylation of 6-deoxyallose to mycinose for effective conversion by the dual function MycG enzyme.

5UHU
SOLUTION CONFORMATION OF CYTOCHROME P450 MYCG WITH MYCINAMICIN IV BOUND
RCSB/PDB
Inspect Structure
See all 3D Structures for mycG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
397Q59523-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project mycG has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mycG there are:
9 structures (20 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis