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hypB (Q57884) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria3


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HF9_A Probable hydrogenase maturation factor HypB Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 67.7 27.3 Yes No
2 empty 2.37 63.9 29.4 No No
3 empty 2.27 66.5 19.5 No No
4 empty 1.91 61.4 20.9 No No
5 empty 2.34 65.5 15.7 No No
6 empty 1.87 67.2 9.6 No No
7 empty 2.23 66.9 11.6 No No
8 empty 2.31 72.3 9.4 No No
9 empty 2.15 67.8 11 No No
10 empty 1.9 63.8 11.2 No No
2HF8_B Probable hydrogenase maturation factor HypB No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 69.6 23 No No
2 empty 2.52 67.4 20.7 No No
3 empty 2.26 64.5 19.8 No No
4 empty 2.24 67.7 13.7 No No
5 empty 2.54 60.8 21.9 No No
6 empty 2.3 64.2 15.4 No No
7 empty 2.18 65.2 13 No No
8 empty 1.64 67.6 10.1 No No
9 empty 2.22 66.6 15.7 No No
10 empty 2.2 66.8 15.8 No No
2HF8_A Probable hydrogenase maturation factor HypB Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 67.9 26.5 Yes No
2 empty 2.19 63.7 24.6 No No
3 empty 1.63 60 21 No No
4 empty 2.16 59.2 17.4 No No
5 empty 2.33 63.2 17.8 No No
6 empty 2.58 68.2 15.5 No No
7 empty 2.21 67.5 11.9 No No
8 empty 2.3 66.6 13.4 No No
9 empty 2.4 68.3 12.4 No No
10 empty 1.93 63.7 11.2 No No
2HF9_B Probable hydrogenase maturation factor HypB Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 68.5 27.6 Yes No
2 empty 2.61 68.1 28.5 No No
3 empty 2.21 65.8 15.2 No No
4 empty 2.16 71.8 12.7 No No
5 empty 2.04 58.5 13.8 No No
6 empty 1.57 66.9 11.9 No No
7 empty 2.26 64.1 16.8 No No
8 empty 2.29 65.3 15.1 No No
9 empty 2.1 67.8 11.1 No No
10 empty 1.91 64.8 13 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed5
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria5

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2HF8_A (3110028) Probable hydrogenase maturation factor HypB PFAM, PFAM, PFAM cobW 2.1Å Yes No
2HF8_A (4052006) Probable hydrogenase maturation factor HypB P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, RecA protein-like (ATPase-domain) (Homo Multimer) 2.1Å Yes No
2HF8_B (4052006) Probable hydrogenase maturation factor HypB P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, RecA protein-like (ATPase-domain) (Homo Multimer) 2.1Å Yes No
2HF9_A (4093101) Probable hydrogenase maturation factor HypB Ferredoxin-like, HMA heavy metal-associated domain, HMA heavy metal-associated domain (Homo Multimer) 1.9Å Yes Yes
2HF9_B (4086621) Probable hydrogenase maturation factor HypB Ferredoxin-like, HMA heavy metal-associated domain, HMA heavy metal-associated domain (Homo Multimer) 1.9Å Yes Yes
2HF9_A (4086621) Probable hydrogenase maturation factor HypB Ferredoxin-like, HMA heavy metal-associated domain, HMA heavy metal-associated domain (Homo Multimer) 1.9Å Yes Yes
2HF9_B (4093101) Probable hydrogenase maturation factor HypB Ferredoxin-like, HMA heavy metal-associated domain, HMA heavy metal-associated domain (Homo Multimer) 1.9Å Yes Yes
2HF9_A (3110031) Probable hydrogenase maturation factor HypB PFAM, PFAM, PFAM cobW 1.9Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score