Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

hypB (Q57884) - Overview - Molecular Target Synopsis

Protein


hypB, Probable hydrogenase maturation factor HypB
UniProt Q57884

Also Known as HYPB_METJA, hypB

Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Homodimer.

2HF8
CRYSTAL STRUCTURE OF HYPB FROM METHANOCALDOCOCCUS JANNASCHII IN THE TRIPHOSPHATE FORM, IN COMPLEX WITH ZINC
RCSB/PDB
Inspect Structure
See all 3D Structures for hypB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
221Q57884-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project hypB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For hypB there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis