Molecular Target Synopsis
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tyrS (Q57834) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed44
Chains with at least one site assessed as druggable using the strict criteria44
Chains with at least one site assessed as druggable using the relaxed criteria44


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5N5V_H Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 76.6 30.4 Yes Yes
2 empty 2.35 66.5 36 No No
3 empty 2.07 61.1 16.8 No No
4 empty 1.32 63.7 26.3 No No
5 empty 2.25 63.7 16.1 No No
6 empty 2.17 59.8 15.1 No No
7 empty 1.8 59.4 13.7 No No
8 empty 1.92 62.3 12.3 No No
9 empty 2.15 64.6 15.1 No No
10 empty 2.16 59.1 16.5 No No
1J1U_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 73.8 27.4 Yes Yes
2 empty 2.18 66.1 31.8 No No
3 empty 1.36 68.4 26.6 No No
4 empty 2.15 57.6 20.3 No No
5 empty 1.96 67.8 12.3 No No
6 empty 1.91 59 14.8 No No
7 empty 2.02 68 13.3 No No
8 empty 1.91 68.3 11.7 No No
9 empty 2.33 64.9 10.9 No No
10 empty 2.24 68.1 10.3 No No
4ND7_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 71.3 50.2 Yes Yes
2 empty 2.13 64.8 28 No No
3 empty 1.31 67.5 22.7 No No
4 empty 2.14 62 16.4 No No
5 empty 2.11 62.9 14.1 No No
6 empty 1.91 60.9 14.1 No No
7 empty 2.23 65.9 11.8 No No
8 empty 1.9 65.8 17.1 No No
9 empty 2.11 67.6 9.7 No No
10 empty 2.42 59.3 9.3 No No
4NX2_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 66.7 36.3 Yes Yes
2 bound 1.89 75.7 30.9 No No
3 empty 2.25 61.7 27.8 No No
4 empty 1.37 64.5 25.5 No No
5 empty 2.33 60.7 21.6 No No
6 empty 1.99 62.9 12.5 No No
7 empty 1.96 56.1 15.4 No No
8 empty 2.31 66.3 17.3 No No
9 empty 1.85 68 10.8 No No
10 empty 2.32 64.1 7.5 No No
4HJX_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 62.9 43.1 Yes No
2 bound 1.85 79.9 29.5 Yes Yes
3 empty 1.51 66.8 29.4 No No
4 empty 1.87 76.7 11.9 No No
5 empty 2.28 55.7 20.2 No No
6 empty 2.06 62.6 15.3 No No
7 empty 1.82 65.7 16.3 No No
8 empty 1.94 66.9 14.5 No No
9 empty 2.13 58.1 14.9 No No
10 empty 2.23 53.8 13.4 No No
3D6U_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 75.5 34.7 Yes Yes
2 empty 2.25 67.2 35 No No
3 empty 2.44 65.4 29.8 No No
4 empty 2.06 64.5 28.8 No No
5 empty 1.37 68.3 21.5 No No
6 empty 2.06 58 14.5 No No
7 empty 1.94 67.3 18.4 No No
8 empty 1.74 65.7 18.9 No No
9 empty 1.9 68.3 8.7 No No
10 empty 2.39 63.2 10.5 No No
1U7X_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 73.3 40.5 Yes Yes
2 empty 2.1 68.4 27.7 No No
3 empty 2.24 64.8 28.5 No No
4 empty 1.77 68.1 14.3 No No
5 empty 2.07 66.6 11.3 No No
6 empty 2.14 54.8 14.7 No No
7 empty 2.33 54.7 15.1 No No
8 empty 2.35 60.2 12.1 No No
9 empty 2.08 69.6 8.9 No No
10 empty 2.32 64.7 10.2 No No
5NSF_D Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 79.2 31.3 Yes Yes
2 empty 2.17 65.7 28.7 No No
3 empty 2.19 62.9 36.2 No No
4 empty 2.02 61.4 31.2 No No
5 empty 2.14 60 20.3 No No
6 empty 2.17 61.9 19 No No
7 empty 2.22 64.7 14.4 No No
8 empty 2.16 70.5 9.4 No No
9 empty 2.12 70.1 13.3 No No
10 empty 1.96 67.4 11 No No
2PXH_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 71.9 56.6 Yes Yes
2 empty 2.16 62.3 23.7 No No
3 empty 1.84 64.6 12.1 No No
4 empty 2.23 60.5 18.8 No No
5 empty 1.28 67.7 14.6 No No
6 empty 1.46 72.6 9.6 No No
7 empty 2 66 12.3 No No
8 empty 2.28 62.2 14.3 No No
9 empty 2.3 64.3 9.1 No No
10 empty 2.68 70.5 8.8 No No
5N5V_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 77.2 28.6 Yes Yes
2 empty 2.35 65.3 29 No No
3 empty 1.29 66.3 26.8 No No
4 empty 2.11 60.8 17.4 No No
5 empty 2.16 62 19.7 No No
6 empty 1.89 67.4 12.9 No No
7 empty 1.97 63 18.4 No No
8 empty 1.84 60.2 12 No No
9 empty 1.76 63.2 12.4 No No
10 empty 2.57 87.4 13 Yes No
3QE4_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 78.8 29.8 Yes Yes
2 empty 2.16 69.4 42.1 No No
3 empty 1.3 66.8 23.2 No No
4 empty 2.37 64.2 20.9 No No
5 empty 1.6 63.2 13.4 No No
6 empty 1.93 60.9 13.7 No No
7 empty 1.84 65 11.9 No No
8 empty 1.8 58.9 14.2 No No
9 empty 2.07 58.4 23 No No
10 empty 2.27 68 11 No No
1U7D_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 77.1 29.1 Yes Yes
2 empty 2.04 66.2 41.8 No No
3 empty 1.76 59.4 29.7 No No
4 empty 2.41 61.4 27.8 No No
5 empty 1.6 61.9 14.1 No No
6 empty 2.34 59.4 20.4 No No
7 empty 2.19 62.7 16.4 No No
8 empty 2.07 70.7 9.3 No No
9 empty 2.86 62.9 14.5 No No
10 empty 1.9 58.3 13.9 No No
5N5V_D Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 76.3 32.4 Yes Yes
2 empty 2.28 68 27.9 No No
3 empty 2.18 61.2 16.2 No No
4 empty 2.02 62 24.5 No No
5 empty 2.25 62.4 17.3 No No
6 empty 2.48 66.4 21.3 No No
7 empty 1.39 63.6 15.8 No No
8 empty 1.89 59.3 15.2 No No
9 empty 1.37 68.5 10.6 No No
10 empty 1.94 56.1 17.6 No No
4HJR_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 78.4 39.9 Yes Yes
2 empty 2.28 66.4 32.7 No No
3 empty 2.46 64.8 16.4 No No
4 empty 1.52 62.8 25.1 No No
5 empty 2.21 59.7 17.1 No No
6 empty 1.89 69.2 14 No No
7 empty 1.99 55.2 14.3 No No
8 empty 2.1 66.1 10.2 No No
9 empty 2 58.9 19.4 No No
10 empty 2.3 68.8 9.8 No No
5N5V_G Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 75.1 29.7 Yes Yes
2 empty 2.31 66.7 27.4 No No
3 empty 2.05 60.4 16.6 No No
4 empty 1.29 66.5 20.7 No No
5 empty 2.21 67.2 17.5 No No
6 empty 2.13 66.8 11.6 No No
7 empty 2.27 60.8 20.6 No No
8 empty 2.03 63.3 15.8 No No
9 empty 1.85 59.4 13.5 No No
10 empty 2.25 64.9 15.9 No No
4HK4_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 74.2 24.7 Yes Yes
2 empty 2.23 67.5 32.6 No No
3 empty 2.31 60.6 17 No No
4 empty 1.33 65.7 23.1 No No
5 empty 2.15 60 18.4 No No
6 empty 2.33 64.2 14.2 No No
7 empty 1.87 60.9 11.9 No No
8 empty 1.9 57.6 13.8 No No
9 empty 1.78 64.1 16.6 No No
10 empty 2.28 60.6 15.3 No No
3N2Y_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 78.7 28.4 Yes Yes
2 empty 2.33 67.3 31.6 No No
3 empty 1.62 64.7 24 No No
4 empty 2.27 70.1 24.9 No No
5 empty 2.33 63.9 18.4 No No
6 empty 2.01 62.8 14.4 No No
7 empty 1.95 67.6 13 No No
8 empty 2.09 60.5 14 No No
9 empty 1.98 66.1 17 No No
10 empty 2.56 69.5 13.3 No No
3D6V_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 79.8 32 Yes Yes
2 empty 2.07 66.6 43.1 No No
3 empty 2.26 67.1 21.8 No No
4 empty 2.46 64.5 25 No No
5 empty 1.33 65.6 21.9 No No
6 empty 2.17 69.2 15 No No
7 empty 2.13 58.5 16.7 No No
8 empty 1.96 67.4 13.5 No No
9 empty 2.03 65.3 15.9 No No
10 empty 1.81 65.3 9.2 No No
5N5U_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 72.7 29.6 Yes Yes
2 empty 2.24 70.4 25.2 No No
3 empty 2.23 61 30.2 No No
4 empty 2.07 63.4 17.1 No No
5 empty 1.46 66.9 22.6 No No
6 empty 2.35 62.1 22.9 No No
7 empty 2.02 61.2 9.4 No No
8 empty 1.97 55.3 14.6 No No
9 empty 2.23 55.8 21.9 No No
10 empty 2.12 68.8 16.7 No No
4NDA_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 72.2 26.4 Yes Yes
2 empty 2.21 58.7 25.6 No No
3 bound 2.04 65.3 16.7 No No
4 empty 2.13 63.6 14.8 No No
5 empty 2.3 58.9 12.8 No No
6 empty 1.32 62 14.5 No No
7 empty 1.79 55.5 14 No No
8 empty 1.46 69 9.7 No No
9 empty 1.86 55.5 14.6 No No
10 empty 1.88 63 9.8 No No
1ZH0_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 76.2 37.5 Yes Yes
2 empty 2.1 62.5 30.8 No No
3 empty 2.47 65.7 28.9 No No
4 empty 2.14 62.8 28.3 No No
5 empty 1.35 65.8 21.7 No No
6 empty 2.36 63.9 20.2 No No
7 empty 1.91 64.2 17.3 No No
8 empty 1.9 59.3 12.9 No No
9 empty 2.06 64.8 11.4 No No
10 empty 2.53 58.7 16.5 No No
2HGZ_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 71.2 49.7 Yes Yes
2 empty 2.33 62.7 31.5 No No
3 empty 1.33 66.7 25.1 No No
4 empty 2.02 64.4 17.5 No No
5 empty 1.74 60.9 12.9 No No
6 empty 1.84 61.4 16.6 No No
7 empty 2.1 67.4 16.5 No No
8 empty 2.42 68.9 17.7 No No
9 empty 2.56 63.6 7.6 No No
10 empty 2.28 80.8 10.1 No No
5N5V_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 72.4 33.5 Yes Yes
2 empty 2.21 67.6 34 No No
3 empty 2.21 62 20.9 No No
4 empty 1.31 68.3 24.3 No No
5 empty 2.06 62.8 18.5 No No
6 empty 2.09 62.7 17.9 No No
7 empty 1.81 58.4 10.9 No No
8 empty 2.23 63.7 14 No No
9 empty 1.94 63.4 16.8 No No
10 empty 1.84 63.2 12 No No
3N2Y_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 77.8 30.9 Yes Yes
2 empty 2.24 66.9 39.5 No No
3 empty 1.31 65.7 24.5 No No
4 empty 2.29 58.6 19.2 No No
5 empty 2.35 70.4 18.3 No No
6 empty 2.04 60.5 15.9 No No
7 empty 1.9 68.2 11.9 No No
8 empty 2 61.1 13.9 No No
9 empty 1.78 59.8 14.1 No No
10 empty 1.91 61.6 20.4 No No
3QE4_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 79 31.5 Yes Yes
2 empty 2.13 67.1 36.1 No No
3 empty 1.31 66.5 24.2 No No
4 empty 1.87 60.5 13 No No
5 empty 1.8 64.2 14.6 No No
6 empty 1.82 57.9 14.1 No No
7 empty 2.14 62.7 15.9 No No
8 empty 1.9 60.4 14.3 No No
9 empty 2.23 65.7 15 No No
10 empty 2.44 61.5 11.5 No No
5U36_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 72.1 39.3 Yes Yes
2 empty 2.12 68.4 35.8 No No
3 empty 2.28 62.2 16.6 No No
4 empty 2.14 66.6 19.7 No No
5 empty 1.38 62.1 14.1 No No
6 empty 1.85 70.1 14.4 No No
7 empty 2.34 61.8 13.1 No No
8 empty 2.02 65.1 13.6 No No
9 empty 2.07 56.5 17.4 No No
10 empty 1.51 84 9.5 No No
1U7D_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 68.7 45.4 Yes Yes
2 empty 2.04 67.5 30.6 No No
3 empty 2.45 61.5 26.4 No No
4 empty 2.13 61.2 13.6 No No
5 empty 1.72 64.6 16.8 No No
6 empty 2.47 59 14.6 No No
7 empty 2.2 67 10.4 No No
8 empty 1.72 68.4 14.9 No No
9 empty 2.58 57.9 14.4 No No
10 empty 2.16 71.4 9.9 No No
5N5V_E Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 76.8 29.1 Yes Yes
2 empty 2.31 65.9 30.3 No No
3 empty 2.05 58.4 18.7 No No
4 empty 2.1 64.4 18.8 No No
5 empty 1.32 65.4 22.9 No No
6 empty 2.52 65.6 16.5 No No
7 empty 2.32 72.2 18.7 No No
8 empty 1.97 60.5 13.9 No No
9 empty 2.13 64.3 11.3 No No
10 empty 2.02 67.1 11.5 No No
5U36_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 72.7 42.2 Yes Yes
2 empty 2.22 66.1 33.9 No No
3 empty 2.18 58.9 28.7 No No
4 empty 2.03 67.3 17.3 No No
5 empty 1.61 68.2 18.1 No No
6 empty 1.75 63.1 13.4 No No
7 empty 2.07 62.2 15.3 No No
8 empty 2.12 66.2 11.7 No No
9 empty 2.46 62.9 15.3 No No
10 empty 2.41 79.2 8.3 No No
5N5V_F Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 77 31 Yes Yes
2 empty 2.22 65.9 36 No No
3 empty 1.91 59.9 17 No No
4 empty 1.3 63.4 22.9 No No
5 empty 2.14 63.4 22.3 No No
6 empty 2.12 61.6 14 No No
7 empty 1.96 64.7 14.4 No No
8 empty 1.85 59.8 13.5 No No
9 empty 1.91 66.1 9.7 No No
10 empty 2.03 59.7 18.6 No No
4ND6_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 73.6 46.4 Yes Yes
2 empty 2.03 67.7 29.6 No No
3 empty 2.26 63.4 29.3 No No
4 empty 2.26 64 18.4 No No
5 empty 2.05 64.4 16 No No
6 empty 2.07 61.7 13.1 No No
7 empty 2.23 64.1 15.8 No No
8 empty 2.57 58.4 17.4 No No
9 empty 2.35 64.9 12.8 No No
10 empty 2.33 76.2 10.3 No No
4PBT_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 74.5 45.7 Yes Yes
2 empty 2.26 62.7 29.7 No No
3 empty 2.1 63.7 29.1 No No
4 empty 1.12 66 22.7 No No
5 empty 2.19 63.6 19.4 No No
6 empty 1.96 61.4 16.8 No No
7 bound 2.22 59.7 12.4 No No
8 empty 2.08 61.4 17.1 No No
9 empty 2.01 66.5 12.9 No No
10 empty 1.91 60.6 14 No No
4PBR_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 73.2 46.8 Yes Yes
2 empty 2.06 63.2 30.6 No No
3 empty 1.29 67.5 22.1 No No
4 empty 2.15 66 16.3 No No
5 empty 2.05 59.3 18 No No
6 empty 2.04 64.3 13.6 No No
7 empty 2.35 59.4 17.5 No No
8 empty 1.91 69.4 9.6 No No
9 empty 2.16 55.9 11.1 No No
10 empty 2.18 63.9 9.6 No No
2AG6_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 77.5 30.8 Yes Yes
2 empty 2.2 65 27.5 No No
3 empty 2.23 62.2 25.1 No No
4 empty 2.39 63.1 30.4 No No
5 empty 1.34 67.7 22.3 No No
6 empty 1.68 74.7 10.8 No No
7 empty 1.88 63.2 12.9 No No
8 empty 2.16 62.2 17.2 No No
9 empty 2.01 65.5 12.6 No No
10 empty 1.89 63.3 16.3 No No
4PBS_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 70.7 53.3 Yes Yes
2 empty 2.05 62.6 33.3 No No
3 empty 2.04 63.3 14.9 No No
4 empty 2.05 62.1 13.2 No No
5 empty 2.17 62.7 13.1 No No
6 empty 2.08 58.6 11.4 No No
7 empty 2.26 64.2 9 No No
8 empty 2.43 67 9.2 No No
9 empty 2.29 62.4 10.5 No No
10 empty 1.78 69.6 9.1 No No
1ZH6_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 74.2 43.8 Yes Yes
2 empty 2.18 66.2 30.7 No No
3 empty 2.23 65.5 27.3 No No
4 empty 1.33 68.9 23.5 No No
5 empty 2.19 64.7 23 No No
6 empty 1.95 61 15.6 No No
7 empty 1.82 59.5 15.2 No No
8 empty 2.21 68.4 20.4 No No
9 empty 1.94 63.3 18.5 No No
10 empty 2.4 65.6 14.6 No No
4HPW_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 77.8 29.2 Yes Yes
2 empty 2.25 67.7 36.7 No No
3 empty 2.24 62 19.8 No No
4 empty 2.19 60.5 21.1 No No
5 empty 2.05 64.4 15.9 No No
6 empty 1.36 63.4 18.6 No No
7 empty 2.09 58.7 14.2 No No
8 empty 1.43 70.5 11.2 No No
9 empty 1.94 66.5 13.3 No No
10 empty 2.15 64.4 12.7 No No
1U7X_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 74.6 47.1 Yes Yes
2 empty 2.23 67.5 28.2 No No
3 empty 2.12 59.7 29.8 No No
4 empty 2.08 62 12.7 No No
5 empty 1.94 63.3 11 No No
6 empty 1.8 66.9 13 No No
7 empty 2.33 68.2 10 No No
8 empty 2.29 57.6 11.2 No No
9 empty 1.94 64.4 11.4 No No
10 empty 2.54 61.9 11.6 No No
5L7P_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 71.4 48.9 Yes Yes
2 empty 2.29 67.2 35.9 No No
3 empty 2.4 59.8 23.7 No No
4 empty 1.99 64.7 12.9 No No
5 empty 1.85 66 12.1 No No
6 empty 2.43 66.5 14.6 No No
7 empty 2.21 72.2 10.7 No No
8 empty 2.09 61.4 14.3 No No
9 empty 2.52 68.4 9.6 No No
10 empty 2.35 61 7.8 No No
5L7P_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 76.5 35 Yes Yes
2 empty 2.08 64.6 35.4 No No
3 empty 2.42 57.6 26.5 No No
4 empty 1.81 58.9 13.7 No No
5 empty 1.35 63.1 17.6 No No
6 empty 2.26 68.9 14.5 No No
7 empty 1.72 74.8 12.8 No No
8 empty 2.11 60.1 11.6 No No
9 empty 2.02 75 7.7 No No
10 empty 1.75 62.4 10.9 No No
4HJX_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 66.1 36.8 Yes Yes
2 bound 1.84 76.7 30.8 No No
3 empty 2.03 67.1 45 No No
4 empty 1.83 58.9 16.2 No No
5 empty 1.95 66.7 12.3 No No
6 empty 1.88 55.3 13.5 No No
7 empty 2.1 56.4 14.5 No No
8 empty 2.08 64.4 10 No No
9 empty 1.95 67.1 16.4 No No
10 empty 1.73 66.5 12.1 No No
4HJR_B Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 74.1 32.2 Yes Yes
2 empty 2.2 66.3 28.9 No No
3 empty 1.33 66.8 25.1 No No
4 empty 2.21 60.2 21.1 No No
5 empty 2.17 66.5 12.2 No No
6 empty 1.98 53.5 14.8 No No
7 empty 1.86 75.5 13.5 No No
8 empty 2.01 65.4 10.7 No No
9 empty 1.88 70.1 8.4 No No
10 empty 2.06 63.7 9 No No
5N5V_C Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 76.6 30.2 Yes Yes
2 empty 2.33 63.9 37 No No
3 empty 2.07 61.5 21.8 No No
4 empty 1.31 65.7 21.9 No No
5 empty 2.32 61.1 19.4 No No
6 empty 1.61 62.8 14.5 No No
7 empty 2.16 58.1 17.9 No No
8 empty 1.92 61.3 14.4 No No
9 empty 2.58 60.9 14.9 No No
10 empty 1.79 63.7 11.4 No No
2ZP1_A Tyrosine--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 75.5 33.3 Yes Yes
2 empty 2.22 67.6 27.7 No No
3 empty 1.32 68.5 25.1 No No
4 empty 1.95 61.4 16.6 No No
5 empty 2.17 64.8 14.9 No No
6 empty 2.05 65.5 12.7 No No
7 empty 2.14 61.4 20.8 No No
8 empty 1.85 59.2 15.1 No No
9 empty 2.2 64.3 16.5 No No
10 empty 2 61.5 12.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed17
Domains assessed as druggable using the strict criteria17
Domains assessed as druggable using the relaxed criteria17

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1J1U_A (83980) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain 1.95Å Yes Yes
1U7D_A (4041160) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain (Homo Multimer) 2.65Å Yes Yes
1U7D_B (4041160) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain (Homo Multimer) 2.65Å Yes Yes
1U7D_B (119616) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain 2.65Å Yes Yes
1U7D_A (119615) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain 2.65Å Yes Yes
1U7X_B (4131917) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain (Homo Multimer) 3Å Yes Yes
1U7X_A (3010599) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 3Å Yes Yes
1U7X_A (4131917) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain (Homo Multimer) 3Å Yes Yes
1ZH0_A (3030618) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 1.9Å Yes Yes
1ZH6_A (3030621) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 2.5Å Yes Yes
2AG6_A (3040395) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 1.9Å Yes Yes
2HGZ_A (3110081) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 2.5Å Yes Yes
2PXH_A (3180314) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 1.97Å Yes Yes
2ZP1_A (3290592) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 1.7Å Yes Yes
3D6U_A (3350732) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 2.2Å Yes Yes
3D6V_A (3350733) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 2.2Å Yes Yes
3N2Y_A (4146103) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain (Homo Multimer) 2.486Å Yes Yes
3N2Y_B (4146103) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, Class I aminoacyl-tRNA synthetases (RS) catalytic domain (Homo Multimer) 2.486Å Yes Yes
3N2Y_A (3630671) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 2.486Å Yes Yes
3QE4_A (3680904) Tyrosine--tRNA ligase Adenine nucleotide alpha hydrolase-like, Nucleotidylyl transferase, UNMATCHED 2.3Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score