Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tyrS (Q57834) - Overview - Molecular Target Synopsis

Protein


tyrS, Tyrosine--tRNA ligase
Enzyme Classification 6.1.1.1
UniProt Q57834

Also Known as SYY_METJA, tyrS

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
306Q57834-1

Sub-cellular localization


UniProt: tyrS is active in the following subcellular-locations: cytoplasm.
GO terms: tyrS is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project tyrS has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tyrS there are:
29 structures (47 chains) solved
21 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


tyrS has been screened with compounds ( bioactivities). (see details)