Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pyrF (Q57700) - Overview - Molecular Target Synopsis

Protein


pyrF, Orotidine 5'-phosphate decarboxylase
Enzyme Classification 4.1.1.23
UniProt Q57700

Also Known as PYRF_METJA, pyrF

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Homodimer.

4LUI
CRYSTAL STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM METHANOCALDOCOCCUS JANNASCHII
RCSB/PDB
Inspect Structure
See all 3D Structures for pyrF

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
213Q57700-1

Sub-cellular localization


GO terms: pyrF is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project pyrF has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pyrF there are:
2 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


pyrF has been screened with compounds ( bioactivities). (see details)