Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP3K19 (Q56UN5) - Overview - Molecular Target Synopsis

Protein


MAP3K19, Mitogen-activated protein kinase kinase kinase 19
Enzyme Classification 2.7.11.1
UniProt Q56UN5

Also Known as M3K19_HUMAN, MAP3K19, RCK, YSK4

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: MAP3K19 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP3K19 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


MAP3K19 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL120, OAW42. (see details)

3D Structures


At greater than 35% identity similarity to MAP3K19 there are:
91 structures (168 chains) solved
79 are solved in complex with at least one small molecule ligand
6 are solved with an approved drug

MAP3K19 is solved in complex with the approved drug(s):

B49/SUNITINIB (4QMZ_A, 6NFY_A, 6NFY_B, 6NFZ_A, 6NFZ_B, 6NG0_A, 6NG0_B),
1N1/DASATINIB (4QMS_A),
DB8/BOSUTINIB (4QMN_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAP3K19 has been screened with 101 compounds (109 bioactivities), 41 compounds have bioactivities that show binding affinity of <= 500nM (45 bioactivities). (see details)