Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MAP3K19 (Q56UN5) - Overview - Molecular Target Synopsis


MAP3K19, Mitogen-activated protein kinase kinase kinase 19
Enzyme Classification
UniProt Q56UN5

Also Known as M3K19_HUMAN, MAP3K19, RCK, YSK4

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: MAP3K19 is active in the following subcellular-locations: cytoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MAP3K19 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

MAP3K19 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL120, OAW42. (see details)

3D Structures

At greater than 35% identity similarity to MAP3K19 there are:
88 structures (162 chains) solved
76 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

MAP3K19 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

MAP3K19 has been screened with 95 compounds (102 bioactivities), 40 compounds have bioactivities that show binding affinity of <= 500nM (44 bioactivities). (see details)