Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ESCO2 (Q56NI9) - Overview - Molecular Target Synopsis

Protein


ESCO2, N-acetyltransferase ESCO2
Enzyme Classification 2.3.1.-
UniProt Q56NI9

Also Known as ESCO2_HUMAN, ESCO2

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ESCO2 is active in the following subcellular-locations: chromosome, nucleus.
GO terms: ESCO2 is active in the following subcellular-locations: cell junction, chromatin, chromocenter, chromosome, Golgi apparatus, nuclear pericentric heterochromatin, nucleoplasm, nucleus, site of double-strand break, XY body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ESCO2 has gain in 0 cell-lines, loss in 10 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, SF_268, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, HCC12, A-431

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to ESCO2 there are:
5 structures (11 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis