Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTBL2 (Q562R1) - Overview - Molecular Target Synopsis

Protein


ACTBL2, Beta-actin-like protein 2
UniProt Q562R1

Also Known as ACTBL_HUMAN, ACTBL2

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
409ENSG00000169067ENST00000423391ENSP00000416706
376Q562R1-1

Sub-cellular localization


UniProt: ACTBL2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTBL2 is active in the following subcellular-locations: cytoplasm, cytoskeleton, extracellular exosome, extracellular space, glutamatergic synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTBL2 has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CL-11, SNU-182, G142

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to ACTBL2 there are:
34 structures (89 chains) solved
24 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTBL2 has been screened with compounds ( bioactivities). (see details)