Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Expression
Gene Copy Number Variation
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hasA (Q54450) - Overview - Molecular Target Synopsis

Protein


hasA, Hemophore HasA
UniProt Q54450

Also Known as HASA_SERMA, hasA

Can bind free heme and also acquire it from hemoglobin. Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium. HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold. Monomer.

5C58
A DOUBLE MUTANT OF SERRATIA MARCESCENS HEMOPHORE RECEPTOR HASR IN COMPLEX WITH ITS HEMOPHORE HASA AND HEME
RCSB/PDB
Inspect Structure
See all 3D Structures for hasA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
188Q54450-1

Sub-cellular localization


UniProt: hasA is active in the following subcellular-locations: secreted.
GO terms: hasA is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project hasA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For hasA there are:
10 structures (15 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis