Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ANKRD39 (Q53RE8) - Overview - Molecular Target Synopsis


ANKRD39, Ankyrin repeat domain-containing protein 39
UniProt Q53RE8

Also Known as ANR39_HUMAN, ANKRD39

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
183ENSG00000213337ENST00000443120, ENST00000393537ENSP00000398321, ENSP00000377170Q53RE8-1

Gene Copy Number Variation

In COSMIC - Cell Lines Project ANKRD39 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MALME_3M, RPMI_8226, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 624 mel, VMRC-LCD, SK-MEL-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, HSMM

(see details)

3D Structures

At greater than 35% identity similarity to ANKRD39 there are:
91 structures (188 chains) solved
8 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ANKRD39 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ANKRD39 has been screened with compounds ( bioactivities). (see details)