Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ANKRD39 (Q53RE8) - Overview - Molecular Target Synopsis

Protein


ANKRD39, Ankyrin repeat domain-containing protein 39
UniProt Q53RE8

Also Known as ANR39_HUMAN, ANKRD39

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
183ENSG00000213337ENST00000443120, ENST00000393537ENSP00000398321, ENSP00000377170Q53RE8-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project ANKRD39 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, RPMI_8226, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 624 mel, VMRC-LCD, SK-MEL-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ANKRD39 there are:
84 structures (181 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ANKRD39 has been screened with compounds ( bioactivities). (see details)