Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLA1A (Q53H76) - Overview - Molecular Target Synopsis

Protein


PLA1A, Phospholipase A1 member A
Enzyme Classification 3.1.1.-
UniProt Q53H76

Also Known as PLA1A_HUMAN, PLA1A, NMD, PSPLA1

Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PLA1A is active in the following subcellular-locations: secreted.
GO terms: PLA1A is active in the following subcellular-locations: acrosomal membrane, extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLA1A has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_257, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-257, SK-MEL-28, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to PLA1A there are:
6 structures (8 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PLA1A has been screened with compounds ( bioactivities). (see details)