TRMT12 (Q53H54) - Overview - Molecular Target Synopsis
TRMT12, tRNA wybutosine-synthesizing protein 2 homolog
Enzyme Classification 220.127.116.11
Also Known as TYW2_HUMAN, TRMT12, TRM12, TYW2
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
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