Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MPPE1 (Q53F39) - Overview - Molecular Target Synopsis


MPPE1, Metallophosphoesterase 1
Enzyme Classification 3.1.-.-
UniProt Q53F39

Also Known as MPPE1_HUMAN, MPPE1, PGAP5

Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins. Interacts with GPI-anchor proteins. Interacts with TMED10.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MPPE1 is active in the following subcellular-locations: cis-golgi network membrane, endoplasmic reticulum-golgi intermediate compartment membrane, golgi apparatus.
GO terms: MPPE1 is active in the following subcellular-locations: cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus, integral component of membrane, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MPPE1 has gain in 2 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, OVCAR_8, DU_145

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, SUM 1315M02, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)