Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MPPE1 (Q53F39) - Overview - Molecular Target Synopsis

Protein


MPPE1, Metallophosphoesterase 1
Enzyme Classification 3.1.-.-
UniProt Q53F39

Also Known as MPPE1_HUMAN, MPPE1, PGAP5

Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins. Interacts with GPI-anchor proteins. Interacts with TMED10.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MPPE1 is active in the following subcellular-locations: cis-golgi network membrane, endoplasmic reticulum-golgi intermediate compartment membrane, golgi apparatus.
GO terms: MPPE1 is active in the following subcellular-locations: cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus, integral component of membrane, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MPPE1 has gain in 2 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, OVCAR_8, DU_145

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, SUM 1315M02, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)