Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SBK1 (Q52WX2) - Overview - Molecular Target Synopsis

Protein


SBK1, Serine/threonine-protein kinase SBK1
Enzyme Classification 2.7.11.1
UniProt Q52WX2

Also Known as SBK1_HUMAN, SBK1

May be involved in signal-transduction pathways related to the control of brain development.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
424ENSG00000188322ENST00000341901ENSP00000343248Q52WX2-1

Sub-cellular localization


UniProt: SBK1 is active in the following subcellular-locations: cytoplasm.
GO terms: SBK1 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SBK1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, SW_620, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 79, NCI-H1930, SK-N-DZ

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: H1-hESC, SK-N-SH, NHLF

(see details)

RNA Interference


SBK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: COV362, MCF12A. (see details)


Screening and Chemistry


SBK1 has been screened with 82 compounds (82 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (6 bioactivities). (see details)