Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

dorA (Q52675) - Overview - Molecular Target Synopsis

Protein


dorA, Dimethyl sulfoxide/trimethylamine N-oxide reductase
Enzyme Classification 1.7.2.3
UniProt Q52675

Also Known as DSTOR_RHOCA, dorA

Catalyzes the reduction of dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO) to dimethyl sulfide (DMS) and trimethylamine, respectively. The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO and TMAO. Homodimer.

1H5N
DMSO REDUCTASE MODIFIED BY THE PRESENCE OF DMS AND AIR
RCSB/PDB
Inspect Structure
See all 3D Structures for dorA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
823Q52675-1

Sub-cellular localization


UniProt: dorA is active in the following subcellular-locations: periplasm.
GO terms: dorA is active in the following subcellular-locations: periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project dorA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For dorA there are:
10 structures (14 chains) solved
10 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis