Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AASDH (Q4L235) - Overview - Molecular Target Synopsis

Protein


AASDH, Beta-alanine-activating enzyme
Enzyme Classification 6.2.1.-
UniProt Q4L235

Also Known as ACSF4_HUMAN, AASDH, ACSF4, U26

Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA.

Isoforms / Transcripts (Protein Coding)


Gene Copy Number Variation


In COSMIC - Cell Lines Project AASDH has gain in 2 cell-lines, loss in 5 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, SW_620, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1599, A-375, NCI-H510A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, AG445

(see details)