Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

AASDH (Q4L235) - Overview - Molecular Target Synopsis


AASDH, Beta-alanine-activating enzyme
Enzyme Classification 6.2.1.-
UniProt Q4L235

Also Known as ACSF4_HUMAN, AASDH, ACSF4, U26

Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA.

Isoforms / Transcripts (Protein Coding)

Gene Copy Number Variation

In COSMIC - Cell Lines Project AASDH has gain in 2 cell-lines, loss in 5 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SNB_19, SW_620, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1599, A-375, NCI-H510A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, AG445

(see details)