Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(Q4KGU2) - Overview - Molecular Target Synopsis

Protein


, 4-hydroxyproline 2-epimerase
Enzyme Classification 5.1.1.8
UniProt Q4KGU2

Also Known as 4HYPE_PSEF5

Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity.

4J9W
CRYSTAL STRUCTURE OF THE COMPLEX OF A HYDROXYPROLINE EPIMERASE (TARGET EFI-506499, PSEUDOMONAS FLUORESCENS PF-5) WITH THE INHIBITOR PYRROLE- 2-CARBOXYLATE
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
310Q4KGU2-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis